【特別講演2】How to conduct large scale randomised trials: tranexamic acid for severe bleeding.

【企画趣旨】

In 1984, the clinical epidemiologists Salim Yusuf and Rory Collins and the eminent statistician Sir Richard Peto, published a seminal paper in Statistics in Medicine entitled “Why do we need some large simple randomised trials?” They argued that large simple trials of the effects on death of widely practicable treatments for common problems are both possible and essential. They pointed out that most treatment effects will be moderate and so to detect these moderate treatment effects we must avoid moderate bias with proper randomisation and avoid moderate random error by having a large sample size. For 30 years, my research team at the London School of Hygiene and Tropical Medicine has followed their recommendation by conducting large scale clinical trials of widely practicable treatments for acute severe bleeding leading to the identification of tranexamic acid as a highly effective and lifesaving treatment. In this lecture I will discuss how to conduct global clinical trials.

【演者】

• 
  Ian Roberts