【特別講演2】How to conduct large scale randomised trials: tranexamic acid for severe bleeding.

【企画趣旨】

In 1984, the clinical epidemiologists Salim Yusuf and Rory Collins and the eminent statistician Sir Richard Peto, published a seminal paper in Statistics in Medicine entitled “Why do we need some large simple randomised trials?” They argued that large simple trials of the effects on death of widely practicable treatments for common problems are both possible and essential. They pointed out that most treatment effects will be moderate and so to detect these moderate treatment effects we must avoid moderate bias with proper randomisation and avoid moderate random error by having a large sample size. For 30 years, my research team at the London School of Hygiene and Tropical Medicine has followed their recommendation by conducting large scale clinical trials of widely practicable treatments for acute severe bleeding leading to the identification of tranexamic acid as a highly effective and lifesaving treatment. In this lecture I will discuss how to conduct global clinical trials.

【演者】

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  Ian Roberts

略歴：

Ian Roberts is Professor of Clinical Epidemiology at the London School of Hygiene & Tropical Medicine. He trained as a paediatrician in the UK and then in epidemiology at the University of Auckland, New Zealand and McGill University, Canada. He is a clinical academic who works collaboratively with health professionals world-wide to conduct large multi-centre clinical trials aimed at improving patient outcomes in life threatening emergencies. He works with others to build global research partnerships to answer questions together that could not be answered by anyone working alone. He has played lead roles in several large trials including the CRASH trials and the Woman trials.